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M9470074.TXT
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1994-07-02
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Document 0074
DOCN M9470074
TI Pneumocystis carinii pneumonia presenting as focal bibasilar uptake on
gallium scan during aerosolized pentamidine prophylaxis [see comments]
DT 9409
AU Katial R; Honeycutt W; Oswald SG; Department of Medicine, Dwight D.
Eisenhower Army Medical Center,; Fort Gordon, Georgia.
SO J Nucl Med. 1994 Jun;35(6):1038-40. Unique Identifier : AIDSLINE
MED/94253900
CM Comment in: J Nucl Med 1994 Jun;35(6):1034-7
AB Radionuclide imaging with gallium is commonly performed in the
evaluation of patients with suspected Pneumocystis carinii pneumonia
(PCP) and is known to be highly sensitive for detection of PCP. We
present a patient with acquired immunodeficiency who developed PCP in
the bases of both lungs while on aerosolized pentamidine prophylaxis. A
gallium scan demonstrated focal uptake in the lung bases, a pattern
generally not associated with PCP, and was extremely useful in guiding
bronchoscopy. An aerosol ventilation scan performed after complete
resolution of the clinical illness demonstrated prominent ventilatory
defects in the lung bases corresponding to the regions of previous
gallium uptake. We speculate that the underlying ventilatory abnormality
may have contributed to poor drug delivery to the lung bases.
Pneumocystis carinii pneumonia must be considered with any focal area of
gallium accumulation in patients receiving aerosolized pentamidine.
DE Adult Aerosols AIDS-Related Opportunistic Infections/PREVENTION &
CONTROL/ *RADIONUCLIDE IMAGING Case Report Gallium
Radioisotopes/*DIAGNOSTIC USE Human Lung/*RADIONUCLIDE IMAGING Male
Pentamidine/*ADMINISTRATION & DOSAGE Pneumonia, Pneumocystis
carinii/PREVENTION & CONTROL/ *RADIONUCLIDE IMAGING JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).